Franz DN, Leonard J, Tudor C, Chuck G, Care M, Sethuraman G, Dinopoulos A, Thomas G, Crone KR: Rapamycin Causes Regression of Astrocytomas in Tuberous Sclerosis Complex, Annals of Neurology 2006; 59:490-498.
There is a project called Community TSC which nearly anyone with a PC can participate. The idle time on your computer will be used to attempt to fit (mathematical models of) drug molecules to (mathematical models of) TSC proteins. Only an occasional connection to the Internet is necessary.
You need not be a computer wizard to participate.
The client runs on Windows 95/98/ME/NT/XP, Solaris, Macintosh.
Two papers in the August 1 issue of Genes & Development explore the genetic interactions between two well-known tumor suppressor proteins, PTEN and TSC2. See http://www.news-medical.net/?id=11778 for full review.
A summary of proceedings at a recent symposium held in the U.S. on the 'Neurobiology of Disease in Children'. This report covers the following topics associated with Tuberous Sclerosis:
Current Approaches to Diagnosis of Tuberous Sclerosis Complex
